Research Direction

Remodeling Catabolism

Cellular protein metabolism balance is regulated by anabolism represented by the endoplasmic reticulum and catabolism represented by lysosomes. Lysosomal dysfunction leads to reduced protein degradation capacity, resulting in excessive accumulation of undegraded proteins, which produces cytotoxicity and ultimately leads to nerve cell death and neurological diseases. LysoX is committed to targeting lysosomal ion channels to remodel and enhance lysosomal metabolic capacity.